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dc.contributor.advisorPaterson, Doctor Lynn
dc.contributor.advisorKar, Professor Ajoy K.
dc.contributor.authorRamsay, William Tulloch
dc.date.accessioned2019-05-06T12:49:39Z
dc.date.available2019-05-06T12:49:39Z
dc.date.issued2018-05
dc.identifier.urihttp://hdl.handle.net/10399/3496
dc.description.abstractSingle cell manipulation can offer great insights into the whole of an organism, the rapidly growing -omics fields are illustrating the heterogeneity that can be found within cell populations and where these subtle differences may be exploited, from fundamental knowledge to diagnostics and therapeutics. The cutting edge of this single cell work requires the application of interdisciplinary research to fully exploit the boundaries being pushed. Biophotonics is one such body of interdisciplinary research, employing light to manipulate biological samples. This work seeks to make use biophotonic techniques as analogues for conventional biological methods. High throughput raster scan photoporation is utilised for attempted transfection, multiple trap optical tweezers are used in an attempt to optically drive mechanical injection of cells and the thermal impact of these optical tweezers, which require high energy densities to confine particles, is tested, via the exploitation of the temperature sensitive emission of quantum dot nanoparticles.en_US
dc.language.isoenen_US
dc.publisherHeriot-Watt Universityen_US
dc.publisherEngineering and Physical Sciencesen_US
dc.rightsAll items in ROS are protected by the Creative Commons copyright license (http://creativecommons.org/licenses/by-nc-nd/2.5/scotland/), with some rights reserved.
dc.titleInternalisation of biophotonic techniques : transfection, injection and thermometryen_US
dc.typeThesisen_US


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